Nitrosamines in Pharmaceutical Drugs
ATNC (Apparent Total Nitrosamine Content) in drugs
The Ellutia 800 Series TEA is the industry standard for nitrosamine detection thanks to its selectivity and sensitivity for nitroso compounds. For testing of pharmaceutical drugs, the 800 Series TEA can be interfaced to a chemical stripping system that allows for rapid testing of ATNC. This quickly gives an accurate result for the total nitrosamine content of a sample showing both volatile and non-volatile components.
Any positive sample can then be further analysed by an 800 Series TEA interfaced to a GC where volatile nitrosamines such as NDMA (N-Nitrosodimethylamine) can be separated and quantified.