Automated Total Nitrosamine Analyser

Rapidly Screen your samples for nitrosamine content down to 1 ppb levels

 

 

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ATNA-Background
 

Analysing Total Nitrosamine Content

 

Nitrosamines are carcinogenic compounds that can be found and formed in many products.  This has been a particular issue in the pharmaceutical industry recently.  Traditional approaches to the analysis, such as by mass spec, have been challenging due to the low detection levels required, the possibility of false positives, or even missing.  This system takes a unique approach of using the combination of a chemical reaction targeting nitrosamine compounds, then detection by a detector with very high selectivity and sensitivity for nitro/nitroso compounds. Rather than speciating the various nitrosamines present, the system gives a single quantitative result down to 1 ppb for the total nitrosamine content. This means both volatile and non-volatile nitrosamines are measured at the same time. This process is automated to allow a high sample throughput.  This makes it ideal for screening a large number of samples rapidly.

 

 

 

 

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Simplify Sample Prep

Some sample types can be analysed directly with no sample prep.

Detect to PPB Levels

Detect down to 1 ppb

 

See All Nitrosamine Content

Detector targets the nitrosamine functional group rather than specific compounds.

 

Increase Sample Throughput

Analyse up to 10 samples per hour

How Does it Work?

Your Sample

Sample Preparation

Some sample types can be added directly to the sample vial; others may require extraction into a solvent first.  Once in the sample vial, the Reagent can be added, the vial sealed and then loaded into the autosampler.

Automated Chemical Reaction Process

The samples are vortexed and then heated.  The chemical reaction causes the NO groups from any nitrosamines present to be released into the headspace of the vial.

Automated Chemical Reaction Process

Headspace sampled

The samples are allowed to cool to ensure vapours from the samples or reagent have condensed.  A sample of the headspace containing the aleviated NO molecules is then injected into the TEA system.

Detection by TEA detector

The carrier gas sweeps the Headspace to the reaction chamber of the TEA.  Here it reacts with Ozone to produce NO in an excited state. As this decays, a photon of light is generated and measured by a PMT.

Detection by TEA detector

Your Result

Positive samples can then be passed for speciated testing.

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