Simplify Sample Prep
Some sample types can be analysed directly with no sample prep.
Nitrosamines are carcinogenic compounds that can be found and formed in many products. This has been a particular issue in the pharmaceutical industry recently. Traditional approaches to the analysis, such as by mass spec, have been challenging due to the low detection levels required, the possibility of false positives, or even missing. This system takes a unique approach of using the combination of a chemical reaction targeting nitrosamine compounds, then detection by a detector with very high selectivity and sensitivity for nitro/nitroso compounds. Rather than speciating the various nitrosamines present, the system gives a single quantitative result down to 1 ppb for the total nitrosamine content. This means both volatile and non-volatile nitrosamines are measured at the same time. This process is automated to allow a high sample throughput. This makes it ideal for screening a large number of samples rapidly.
Some sample types can be analysed directly with no sample prep.
Detect down to 1 ppb
Detector targets the nitrosamine functional group rather than specific compounds.
Analyse up to 10 samples per hour
Your Sample
Sample Preparation
Some sample types can be added directly to the sample vial; others may require extraction into a solvent first. Once in the sample vial, the Reagent can be added, the vial sealed and then loaded into the autosampler.
Automated Chemical Reaction Process
The samples are vortexed and then heated. The chemical reaction causes the NO groups from any nitrosamines present to be released into the headspace of the vial.
Automated Chemical Reaction Process
Headspace sampled
The samples are allowed to cool to ensure vapours from the samples or reagent have condensed. A sample of the headspace containing the aleviated NO molecules is then injected into the TEA system.
Detection by TEA detector
The carrier gas sweeps the Headspace to the reaction chamber of the TEA. Here it reacts with Ozone to produce NO in an excited state. As this decays, a photon of light is generated and measured by a PMT.
Detection by TEA detector
Your Result